Doctors

About Me:

Head, Department of Neurology In-charge of Parkinson’s Disease and Movement Disorders Program Director, RGCM Research Center Vice Chairman Institute of Neurosciences- Kolkata 185/1 AJC Bose Road, Kolkata 700017,India Member of Executive Committee and Treasurer, Movement Disorders Society of India Member, Education Committee; Movement Disorders Society- AOS. Founder President, Parkinson's Disease Patient Welfare Society of Kolkata (PDPWSK) Spinocerebellar Ataxia - 12 (SCA 12) Consortium

PROFESSIONAL MEMBERSHIPS

  • International Parkinson and Movement Disorder Society (IPMDS)
  • Movement Disorders Society of India (MDSI)
  • Indian Academy of Neurology (IAN)
  • American Academy of Neurology (AAN)
  • Neurological Society of India (NSI)
  • Indian Science Congress (ISC)
  • Founding Member of Movement Disorders Society Of India (MDSI)
  • Founder President of Parkinson’s Disease Patients Welfare Society Kolkata (PDPWSK)
  • Founder President of Spinocerebellar Ataxia - 12 (SCA 12) Consortium Kolkata

HONORS

  • Elected as MDS-AOS Education Committee member for 2019-2021 term
  • Bishista Chikitsha Samman from Govt of West Bengal in 2019
  • Received Best Poster award at Indian Academy of Neurology Conference (IANCON), 2015
  • Selected for India Academy of Neurology Queen Square fellowship (2006-2007)
  • Received Patricia Harris award for best studentship (2006-2007)

GRANTS RECEIVED:

1. Indian Academy of Neurology Research Grant Scheme-2020.

Funding agency: The Indian Academy of Neurology Research Grant Scheme
Project Title: “ Effect of Noninvasive Cervical Vagus Nerve Stimulation on Levodopa Induced Dyskinesia - A Crossover Randomized Controlled Trial”
Year received: 2020

2. DST WOS-A fellowship - Mentor :

Funding agency: Department of Science and Technology, Govt of India Women Scientist Scheme A from DST, India
Project Title: “ Effect of Non-Invasive Vagus Nerve Stimulation in Oxidative Stress and Freezing of Gait in Parkinson’s Disease Patients
Year received: 2018

3. DST Inspire Fellowship- joint supervisor:

Funding agency: Department of Science and Technology, Govt of India
Project Title: Biomarkers of Parkinson’s disease: A Translational Approach and Identification of its clinical implications
Year received: 2017

4. Co investigator in Prof Stuart Bakers grant:

Funding agency: MRC Concept Grant
Project Title: Stop Signal Reaction Time in movement disorders
Year received: 2019-20

5. Genome Wide Association Study:

Funding agency: One of the Centre of a multicentre study funded by MJ Fox Foundation
Project Title: Genome Wide Association Study in Parkinson’s Disease
Year received: 2019

6. Clinical Trials

Funding agency: KASHIV BIOSCIENCES LLC, USA
Project Title: An open-label, parallel, single ascending dose (SAD) study investigating the pharmacokinetics, dose proportionality, and safety of K102 in patients with Parkinson’s disease (PD).
Year received: 2020
Funding agency: Pharmazz India Pvt. Ltd
Project Title: A Prospective, Multi-Centric, Randomized, Double-Blind, Parallel, Phase-III Clinical Study to Assess Efficacy of PMZ-1620 along with Standard Treatment in Patients of Acute Ischemic Stroke.
Year received: 2020
Funding agency: Macleods Pharmaceuticals Ltd
Project Title: A Prospective, Randomized, Double-blind, Placebo-Controlled Proof-of-concept to study the clinical efficacy and safety of L-seriene supplement along with standard treatment in Patients with Alzheimer’s Disease
Year received: 2020
Funding agency: Novartis Healthcare Pvt Ltd (NHPL)
Project Title:A 12-week double-blind, randomized, multi-center study comparing the efficacy and safety of once monthly subcutaneous AMG 334 against placebo in adult episodic migraine patients (EMPOwER).
Year received: 2019
Funding agency: Bioxcel Corporation US & India
Project Title:A Randomized, Blinded, Prospective, Placebo Controlled, Investigator Initiated Study to Evaluate Efficacy and Safety of Dexmedetomidine Injection in the agitated subjects with Mild Probable Alzheimer’s Disease.
Year received: 2018
Funding agency: AstraZeneca Pharmaceutical Company
Project Title:A Randomised, Double-Blind, Placebo-Controlled, International, Multicentre, Phase III Study to Investigate the Efficacy and Safety of Ticagrelor and ASA Compared with ASA in the Prevention of Stroke and Death in Patients with Acute Ischaemic Stroke or Transient Ischaemic Attack
Year received: 2018

SOCIAL INTERACTIONS

  • Delivered various talksfor the awareness of Parkinson’s disease at various NGOs & clubs like Bengal Rowing Club, LION’s club, Rotary club etc.
  • Under the umbrella of I-NK, clinicians and researchers of the institute have started a society for welfare of patients with Parkinson's Disease and for their care-givers. We organize weekly program at two centers of Kolkata (one each in North and South). The program is aimed to foster camaraderie among patients and their care givers. It gives them a platform where they share their joy and sorrow. The program is monitored by trained professionals who teach patients and their care-givers about the various aspects of living with Parkinson's Disease and includes sessions of physiotherapy, dance therapy, psychological support. Renowned dancer Mrs. Alakanada Roy is regularly helping us in incorporating dance movements as a part of rehabilitation in patients with Parkinson's Disease.
  • I-NK organizes a larger monthly program in its seminar hall where clinicians, rehab specialists and psychologists mingle with patients and their care-givers in a semi-formal setting. Every month we have participation of more than 100 patients and care-givers. These programs invigorate the patients and their family members and provide them zeal to live well and with optimism.
  • I-NK also organizes yearly program on World Parkinson's Disease day on the 11th of April every year. Apart from patients and care-givers people, from various strata of society participate in the program.
  • The patients of PD attending the clinics at I-NK have formed a cultural and choir group and they perform at various functions regularly.
  • Every year PD patients coming to I-NK along with the doctors participate in Tata Steel marathon to create awareness about the disease in general public.

ONGOING RESEARCH

  1. Dr Supriyo Choudhury (MBBS, MD) is a qualified Clinical Pharmacologist and senior research fellow in Dr Hrishikesh Kumar’s movement laboratory. His area of interest is neurophysiology and neuropharmacology. He is working in close collaboration with Prof. Stuart Baker, a renowned neuroscientist from Newcastle University, UK. He is currently conducting an investigator initiated clinical trial, where an extensor galvanic stimulator device is tested on stroke survivors. The investigators predict it will improve the hand function of these patients through strengthening of alternative motor tract (reticulospinal tract). Patient themselves can operate this pint-sized device at their home. The result of the study is expected by the middle of 2018. He has also explored the contribution of brain-stem region in the pathogenesis of focal hand dystonia through blink-reflex studies. Interestingly, the group has observed a characteristic oscillation pattern in this disorder.
  2. Dr Rebecca Banerjee, a senior research fellow, along with two PhD fellows Mr. Koustav Chatterjee and Mr. Akash Roy under the supervision of Dr. Hrishikesh Kumar are currently working on Parkinson’s disease (PD) and related inflammation. Inflammation seems to be one of the leadingfactors resulting in PD. This postulate has been supported by number of studies from a few Universities in the West. However, it is an extremely complex process involving numerous mediators. Therefore, the story of inflammation in PD has not been spoken beautifully yet and identification of the most important mediator in link with PD severity should be a significant development. We predict targeting specific mediators like inflammation can be further developed as an effective treatment. We hypothesize the association of certain inflammatory markers with disease severity might be further explored as diagnostic markers or targets for therapy in future. We are focusing on the level of alpha–synuclein and its different form in PD and its relation with neuro-inflammation.
  3. Gait disorders are common yet difficult to treat in advanced PD patients. Ms. Banashree Mondal,DST-Women Scientist-A, working under the supervision of Dr. Hrishikesh Kumar is looking into the gait disorders, especially freezing of gait in PD, using an electronic walkway, GAITRite. This electronic mat is embedded with several sensors that provide information about gait parameters of patients with walking difficulty on 2-D dimensional spatio-temporal axis. We are using a non-invasive vagus nerve stimulator to observe its effect on gait parameters in freezing of gait in PD patients. This might help us in improving gait in these patients which otherwise is difficult to treat. We are also trying to differentiate various gait patterns in different types of neurodegenerative disorders. This will help us to improve the diagnosis as well as quality of life. Two of the research fellows went to Newcastle University, UK to receive training in GAITRite and Deep brain stimulation for 15 days. They underwent special training program for the gait recording, gait analysis using the GAITRite instrument. They also got trained in maneuvering of the parameters done in deep brain stimulation in PD patients.
  4. Single nucleotide polymorphisms (SNPs) in dopamine pathway genes are associated with diverse type of altered function of dopamine. Polymorphisms may be associated with peak dose dyskinesia. Most of these SNPs were reported within Caucasians. SNPs influencing LID in PD patients from India is unknown. Indian population is genetically diverse. Therefore, polymorphisms of specific dopamine pathway genes could be involved in the prevalence of LID among PD patients in India compared to disease duration and daily L-Dopa dose matched cohort of PD without LID. Ms. Swagata Sarkar, a Ph. D fellow under the guidance of Dr. Rebecca Banerjee and Dr. Supriyo Choudhury with the supervision of Dr. Hrishikesh Kumar currently working on Dopamine pathway gene polymorphisms involved in Levodopa Induced Dyskinesia in Parkinson’s Disease.
  5. Ability to efficiently stop just before the execution of a movement, in response to an external cue requires heathy executive function. There are number of movement disorders that slow the ability of movement-stopping. Estimation of movement-stopping is possible through - Stop Signal Reaction Time (SSRT). As a collaborative project I-NK has developed a portable device to assess Reaction time (RT) and stop signal reaction time (SSRT). With this device recently Dr. Supriyo Choudhury, Mr. Akash Roy under the guidance of Dr. Hrishikesh Kumar and Dr. Stuart Baker have done assessment of SSRT to measure DBS responsiveness among PD sufferers.Cerebro-cerebellar interaction is an important aspect in response inhibition. In Spino Cerebellar Ataxia (SCA), Basal ganglia and Cerebellar involvement has been documented. Hence response inhibition by measuring SSRT has been assessed among SCA patients by Ms. Ummatul Siddique, a research fellow of this lab. Another important aspect of response inhibition is Cognition, which get hampered in diseases like – Alzheimer’s Dementia (AD), Vascular dementia etc. Hence SSRT was observed among AD sufferers by Ms. Simin Rahman, another research fellow in this lab. Both of the works were done under the supervision of Dr. Supriyo Choudhury and Dr. Hrishikesh Kumar. Psychotropic drugs like – Benzodiazepines could affect movement stopping because of the involvement of GABAergic pathway. Therefore, effect of Diazepam in movement stopping was assessed by Senior research fellow Dr. Supriyo Choudhury along with Ph.D fellow Ms. Swagata Sarkar and another research fellow Mr. Ravi Singh of this lab, in healthy volunteers under the supervision of Dr. Hrishikesh Kumar and Dr. Stuart Baker.
  6. I-NK is now an important part of global mega-clinical trial of a new antiplatelet drug which has shown very promising results in patients with cardiac ischemic injury but rarely explored in stroke and Transient Ischemic attack patients. Apart from that we are also conducting another global multi-centric trial on migraine patients. Our site is competing in recruitment and data-quality with premier research hospitals like All India Institute of Medical Sciences (AIIMS) and till now we are climbing the ladder quite fast.